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Clinical Significance of Urine Bilirubin

Liver damage or an obstructed bile duct allows conjugated bilirubin to enter the circulation and ultimately to appear in the urine. Patients with clinical jaundice due to hepatitis or cirrhosis will have bilirubinuria.
If the jaundice is due to red cell destruction, there is an increase in unconjugated bilirubin, which the kidneys cannot excrete.