As noted earlier, in this case study the laboratory's protocol is to set up a mini-panel, providing these criteria are met:
- Mother is Rh-negative and has been tested on two separate occasions;
- Laboratory has confirmed administration of RhIg prophylaxis;
- Result of current antibody screen is positive and typical of anti-D due to RhIg;
- There is no record or history of an unexpected antibody.
All criteria were met and a selected mini-panel was set up to confirm the presence of anti-D and exclude possible co-existing maternal antibodies.
Other clinically significant antibodies have implications for possible HDFN and for transfusion to both the mother and newborn, thus must be excluded.