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The page below is a sample from the LabCE course Hemolytic Disease of the Fetus and Newborn. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Clinical Relevance of D Phenotypes

Clinically relevant information on D phenotypes can be summarized as follows:

D phenotype
D antigen
expression
Rh(D) typing
Produce
anti-D
RBC
to transfuse
RhIG
recommended**
D+NormalDAT
No
D+ or D–
No
Weak DNormal but weakIATNoD+ or D–No
Partial DAlteredDAT* & IATYesD–Yes
Partial weak DAltered & variableDAT* & IATYesD–Yes
DNoneIATYesD–Yes
* Depending on anti-D reagent used
** USA, UK and parts of Canada