The page below is a sample from the LabCE course Hemolytic Disease of the Fetus and Newborn. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Hemolytic Disease of the Fetus and Newborn (online CE course) »
How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 94 CE courses, most popular
$95 Add to cart
Pick Your Courses
Up to 8 CE hours
$50 Add to cart
Individual course$20 Add to cart

Molecular Genotyping: Differentiating Between Weak D and Partial D

Some individuals have a variant RHD gene that encodes a reduced concentration of D antigen (weak D) or a D antigen with missing D epitopes (partial D). Various anti-D reagents react differently with these red cells and interpreting Rh(D) type can vary with the method used (ie, tubes, solid phase, or gel).
Differentiating between weak D and partial D is important in pregnant women. Those with partial D, but not usually weak D, may make anti-D and should be considered D negative for transfusion and as RhIg candidates. Currently, serologic reagents cannot distinguish the two D variants, but RHD genotyping can.