The page below is a sample from the LabCE course Hemolytic Disease of the Fetus and Newborn. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Hemolytic Disease of the Fetus and Newborn (online CE course) »
How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 94 CE courses, most popular
$95 Add to cart
Pick Your Courses
Up to 8 CE hours
$50 Add to cart
Individual course$20 Add to cart

Choosing Donor RBC for IUT and IVT

Blood for intrauterine transfusion (IUT) should meet the following criteria:
  • Group O negative or compatible with both maternal and fetal types if known.*
  • Negative for the antigens that correspond to the maternal antibodies
  • Crossmatch compatible with maternal serum.
  • Irradiated to prevent transfusion-associated graft-versus-host disease (TA-GVHD) in the fetus.
  • Cytomegalovirus (CMV) “safe” (leukoreduced and/or CMV seronegative).
  • Negative for HbS to prevent sickling in lower fetal O2 tensions.
Optimally, the blood is less than 7 days old to reduce the risk from accumulated storage lesion products such as potassium and to avoid decreased levels of 2,3-DPG found in older stored blood, which reduces the ability of hemoglobin to deliver oxygen to the tissues. The hematocrit of the unit should generally be 75% - 85% to deliver maximum numbers of RBCs while minimizing the risk of volume overload in the fetus.
*Some laboratories use red cells that are also K-negative since the K antigen is very immunogenic. This also applies to exchange transfusions.