Toxic Granulation Example
The neutrophils found in Chediak-Higashi must be differentiated from toxic granulation. In conditions causing toxic granulation, the granules are smaller and more numerous. In toxic granulation, neutrophils are usually the only cells affected.
In Chediak-Higashi anomaly, eosinophils, basophils, lymphocytes and monocytes are affected. In eosinophils larger than normal eosinophilic granules may be seen, basophils may exhibit larger than normal basophilic granules, lymphocytes, large azurophilic granules. Larger pale granules/bodies may appear in monocytes.