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May-Hegglin Anomaly

May-Hegglin anomaly is an autosomal dominant condition characterized by the presence of pale blue inclusions in neutrophils called May-Hegglin bodies. May-Hegglin bodies, which are described as Döhle-like, are prominent and randomly distributed throughout the cytoplasm; inclusions can also occur in eosinophils, basophils, and monocytes. Additional findings include giant platelets, and occasional thrombocytopenia.

Acquired forms of this anomaly may also occur as a result of the use of cytotoxic drugs.

The blue arrow in the image points to a May-Hegglin body . The red arrow indicates a giant platelet, a characteristic that also helps to identify the anomaly.