Delayed HTR often goes undetected as the symptoms are usually mild and subclinical (death has occurred, but rarely).
Symptoms may not occur until days after transfusion when the patient has left the hospital. Donor red cell destruction is usually by extravascular hemolysis (EVH).
Signs and symptoms can include:
- Fever with or without chills
- Unexplained drop in hemoglobin and hematocrit
- Transient jaundice due to elevated serum bilirubin