Mechanisms

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The page below is a sample from the LabCE course Immune Hemolytic Anemias. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Mechanisms

Four mechanisms of drug-induced immune antibodies are thought to be associated with red blood cell sensitization and a positive direct antiglobulin test (DAT). These mechanisms are:

  • Drug adsorption
  • Immune complex
  • Membrane modification (non-immune adsorption of proteins)
  • Induction of autoimmunity