Autoimmune Hemolytic Anemia (AIHA): Introduction

How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 154 CE courses, most popular
$95Add to cart
Pick Your Courses
Up to 8 CE hours
$50Add to cart
Individual course$20Add to cart
Need multiple seats for your university or lab? Get a quote
The page below is a sample from the LabCE course Immune Hemolytic Anemias. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Immune Hemolytic Anemias (online CE course)
Autoimmune Hemolytic Anemia (AIHA): Introduction

Autoantibodies are immunoglobulins directed against self antigens. Most autoantibodies react with high-incidence red cell antigens. Recognition of these antibodies is important during serologic testing.
Autoantibodies may complicate routine testing by causing ABO and Rh typing problems.
AIHA is usually confirmed by a positive direct antiglobulin test (DAT) and demonstration of the autoantibody in the plasma or eluate.
AIHA is classified as either cold-reactive or warm-reactive. The table above lists different types of AIHA and the antibody classes involved. These will be discussed in detail on the following pages.
Autoimmune Hemolytic AnemiaAntibody TypeComplement Association
Warm Autoimmune Hemolytic Anemia (WAIHA)IgG autoantibodiesSometimes
Cold Agglutinin Syndrome (CAS)IgM autoantibodiesYes
Mixed-Type (Serological features of both warm and cold autoantibodies)Both IgM and IgG autoantibodies

Yes
Paroxysmal Cold Hemoglobinuria (PCH)IgG biphasic hemolysinYes