Scl-70 Pattern

How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 145 CE courses, most popular
$95Add to cart
Pick Your Courses
Up to 8 CE hours
$50Add to cart
Individual course$20Add to cart
Need multiple seats for your university or lab? Get a quote
The page below is a sample from the LabCE course Autoimmune Diseases and Antinuclear Antibody Testing: Methods and Staining Patterns. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Autoimmune Diseases and Antinuclear Antibody Testing: Methods and Staining Patterns (online CE course)
Scl-70 Pattern

Antibodies to Scl-70, also known as anti-topoisomerase I antibodies, produce three ANA patterns: homogeneous, speckled, and nucleolar. This is because the Scl-70 antigen is present in all three areas.
In cases of mixed homogeneous and speckled ANAs, follow-up testing for anti-dsDNA and anti-ENA antibodies is necessary. When mixed patterns are titered, the endpoint for each pattern is reported.
This pattern is reported as "ANA positive, Homogeneous, Nucleolar and Speckled; titering is necessary." (It should be noted that anti-Scl-70 cannot be identified simply by the ANA patterns. Follow-up ENA testing is necessary.)

Scl-70 IFA
Scl-70 Colorzyme