Auto Control and O Cell Control

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The page below is a sample from the LabCE course ABO Typing Discrepancies. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Auto Control and O Cell Control

An auto control should be included when resolving reverse typing discrepancies that may be caused by autoantibodies.
Auto control = patient plasma + patient red cells
An O cell control should be included when resolving reverse typing discrepancies that may be caused by alloantibodies. Antibody screening cells are group O, so performing an antibody screen is the same thing as completing an O control.
O control= patient plasma + reagent O cells (screen cell II)