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The page below is a sample from the LabCE course Chronic Kidney Disease. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Direct Measurement of the GFR (2 of 2)

Markers for direct measurement are very accurate, but cumbersome to use on a routine basis. As such, they are generally employed only in situations where other estimates of GFR are inadequate.
Patients where direct measurement may be beneficial over routine estimation include (Clarke, 2016):
  • Those that are very young or old
  • Those that are malnourished, obese, or are vegetarian/vegan
  • Those with disease that affects skeletal muscle
Other situations may include patients that are being evaluated for kidney donation or are missing large portions of muscle mass (e.g., paraplegia).