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The page below is a sample from the LabCE course Beta Thalassemia. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Chromosome 11 Beta Thalassemia Intermedia B0/B+, B0/B

In beta thalassemia intermedia B0/B+, there is one completely deleted or inactive beta chain gene, while the other is partially deleted or inactive.

This state also results in Hb A production of 55%-75% of normal.

(drawing modified from Harmening, 1999)

In beta thalassemia intermedia B0/B, there is one completely deleted or inactive beta chain gene, while the other gene is completely normal. (not shown)