Coagulation Disorders - Inherited

How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 154 CE courses, most popular
$95Add to cart
Pick Your Courses
Up to 8 CE hours
$50Add to cart
Individual course$20Add to cart
Need multiple seats for your university or lab? Get a quote
The page below is a sample from the LabCE course Fundamentals of Hemostasis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Fundamentals of Hemostasis (online CE course)
Coagulation Disorders - Inherited

Von Willebrands Disease is a platelet disorder characterized by a functional defect in Von Willebrands factor (vWF) itself. Because Factor VIII binds to VWF for transport in the blood, people with VWF deficiencies can also have decreased quantities of functional Factor VIII. Although VWF problems affect platelet function, these patients usually have normal platelet counts. As far as genetics and inheritance, both men and women are affected equally.

Von Willebrands factor is essential for platelet binding, therefore, a defect in vWF causes impaired platelet adhesion and aggregation.
The treatment for persons with Von Willebrands Disease who are bleeding involves the administration of the modified antidiuretic hormone, deamino-D-arginine vasopressin (DDAVP). DDAVP can temporarily raise levels of vWF and factor VIII. Cryoprecipitate formerly was the method of treatment but has since been replaced with DDAVP.