An Introduction to the Fundamentals of Hemostasis, continued

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An Introduction to the Fundamentals of Hemostasis, continued

  • The ability to control bleeding hinges primarily on the availability of both platelets and coagulation factors and their adequate functionality.

  • It is important to note, however, that there are limits to the size or the degree of damage that can be controlled and repaired without outside (medical) intervention.

  • As one may expect, and the prior chart illustrates, damage to a larger vessel yields a more substantial bleed and, in turn, consumes a greater quantity of coagulation components.

  • These variables can radically alter the effectiveness of hemostatic control mechanisms.
  • As we will discover later in the course, other variables impact the effectiveness of hemostatic mechanisms, such as acquired disease states and inborn metabolic pathway defects.

  • For now, however, our focus will be on the mechanisms, processes, and components which work together to achieve coagulation or the cessation of blood flow from a damaged vessel.

  • Note: Despite the fact that the word hemostasis refers to not just the coagulation mechanism but also the function and interaction with the vascular and extravascular systems and platelets, the terms hemostasis and coagulation are commonly used interchangeably and can be seen in this course.