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The page below is a sample from the LabCE course Alpha Thalassemia. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Chromosome 16 Alpha Thalassemia Intermedia

When three gene loci of alpha chains are deleted (--/-α) or inactive, only 70-90% of Hemoglobin A is made.

The excess beta chains that remain unpaired (due to the missing alpha chains) form tetramers beta chains called Hemoglobin H.