CYP450s

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CYP450s

Many CYP450 enzymes have been characterized, and the substrates (drugs) that each can recognize have been worked out to a large extent.
The major subfamilies of CYP450 enzymes, which have to-date been associated with significant polymorphisms that affect drug disposition are:
  • CYP1A2
  • CYP2C9
  • CYP2C19
  • CYP2D6