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The page below is a sample from the LabCE course Clostridium difficile Infection (CDI): Overview, Laboratory Tests and Updated Guidelines.. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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References

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The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins, Chen S et al, Toxins (Basel), 2015 Dec; 7(12): 5254–5267. Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690124/
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Current knowledge on the laboratory diagnosis of Clostridium difficile infection: Review of diagnostic testing: Adrián Martínez-Meléndez, et al,World J Gastroenterol. Mar 7, 2017; 23(9): 1552-1567 available athttps://www.wjgnet.com/1007-9327/full/v23/i9/1552.htm
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Clostridium difficile Diagnostic Testing: Quest Diagnostics, available at https://education.questdiagnostics.com/faq/FAQ136

Planche TD, et al. Differences in outcome according to Clostridium difficile testing method: a prospective multicenter diagnostic validation study of difficile infection. The Lancet. 2013;13(11):936-945.
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Package insert TECHLAB® C. DIFF QUIK CHEK COMPLETE®. http://www.alere.com/en/home/product-details/c-diff-quik-chek-complete.html
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Cohen SH, Gerding DN, Johnson S, et al. 2010. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31:431-455.

New IDSA/SHEA Clostridium Difficile Guidelines ,Clin Infect Dis; ePub 2018 Feb 15; McDonald, et al: Published,February 26, 2018 , available athttps://www.mdedge.com/idpractitioner/clinical-edge/summary/antimicrobial-resistance/new-idsa/shea-clostridium-difficile
McDonald LC, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). [Published online ahead of print February 15, 2018]. Clin Infect Dis. doi:10.1093/cid/cix1085.
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New guidelines and studies suggest improved approaches to C. difficile testing, Sherry A. Dunbar, June 21, 2018, MLO, available at https://www.mlo-online.com/new-guidelines-and-studies-suggest-improved-approaches-to-cdifficile-testing
Roecker A, et al, Gastrointestinal Infections and Enterotoxigenic Poisoning: Taken from DiPiro JT, et al, Pharmacotherapy: A Pathophysiologic Approach, 10e New York, NY: McGraw-Hill; available athttps://www.pharmacytimes.com/contributor/ayesha-khan-pharmd-bcps/2018/03/practice-pearls-from-the-2018-clostridium-difficile-treatment-guidelines

Multistep algorithm testing accurately identifies C. diff patients who need treatment, Jodie Lee, July 2018, MLO, available at
Other References:
Surawicz CM, Brandt LJ, Binion DG, et al. Guidelines for the diagnosis, treatment and prevention of Clostridium difficile infections. Am J Gastroenterol. 2013;108:478-498.
American Society for Microbiology. A practical guidance document for the laboratory detection of toxigenic Clostridium difficile. Published September 21, 2010, available at https://www.asm.org/images/pdf/Clinical/clostridiumdifficile9-21.pdf.
Johnson S. Recurrent Clostridium difficile infection: a review of risk factors, treatments, and outcomes. J Infect. 209;58:403-410.
Gade R, Turett G. The utility of repeated stool toxin testing for diagnosing Clostridium difficile colitis. South Med J 2009; 102:1007