Interpreting the Mixing Study Results: Case Study One

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The page below is a sample from the LabCE course Detecting and Evaluating Coagulation Inhibitors and Factor Deficiencies. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Interpreting the Mixing Study Results: Case Study One

A young patient is admitted from the emergency room with petechial bruising. The attending physician orders a battery of tests, including a PT and aPTT. The laboratory performs the requested testing, and the result of the aPTT is normal; however, the PT is prolonged:
TestPatient ResultReference Range
PT 38 sec. 11-13 sec.
aPTT 32 sec. 21-34 sec.
The physician then decides to order a mixing study for further analysis since the patient is not taking any oral anticoagulants, nor do they meet the known patient history associated with prolonged PT results.