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The page below is a sample from the LabCE course Detecting and Evaluating Coagulation Inhibitors and Factor Deficiencies. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Coagulation Inhibitors and Coagulation Screening Tests

Patients with factor-specific coagulation inhibitors will have a prolonged prothrombin time (PT) and/or aPTT test results (depending on the coagulation factor that is targeted by the inhibitor). Clinically, this is associated with abnormal clotting and bleeding complications.
A prolonged aPTT, and sometimes PT, is seen with lupus anticoagulant. The antibody combines with the phospholipids on the surfaces of test reagents that are used in the aPTT test, and sometimes in the PT test, prolonging the test result(s). Because of this, the aPTT is not corrected in mixing studies of patients with lupus anticoagulant. Clinically, lupus anticoagulant is associated with thrombosis and not with bleeding symptoms.