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The page below is a sample from the LabCE course Clostridium difficile Infection (CDI): Overview, Laboratory Tests and Updated Guidelines.. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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CDI: Risk Factors for CDI

Certain factors tend to increase the risk for CDI including:

  • Taking or having recently taken antibiotics or taking broad-spectrum antibiotics that target a wide range of bacteria.
  • Taking multiple antibiotics or taking antibiotics over a long period.
  • Taking medication for stomach acid including proton pump inhibitors.
  • Staying in a health care facility.
  • Having a serious illness or medical procedure such as inflammatory bowel disease or colorectal cancer or a weakened immune system. Risk of CDI is also greater if an individual has had abdominal surgery or a gastrointestinal procedure.
  • Being 65 or older.
  • Having a previous CDI increases the risk for a recurrent CDI.