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The page below is a sample from the LabCE course Drug Metabolism. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Opiates: Hydromorphone

Hydromorphone Metabolism
  • Hydromorphone is metabolized to hydromorphone-3-glucuronide.
Hydromorphone has a half-life of 3 to 9 hours and can be detected in the urine for 2 to 4 days after ingestion.
  • For patients prescribed only hydromorphone, hydromorphone alone should be detected in the urine sample.
  • If hydrocodone is detected, hydromorphone could be present as a metabolite rather than ingestion.