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The page below is a sample from the LabCE course Drug Testing Methods in the Clinical Toxicology Laboratory. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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The half-life of oxycodone is two to six hours and can be detected in the urine for two to four days after ingestion.
Because oxycodone is metabolized to oxymorphone, both oxycodone and oxymorphone can be detected in patients taking oxycodone.
Since the cross reactivity of oxycodone and its metabolites in opiate immunoassays is very low, most laboratories employ the use of a separate oxycodone screen in addition to the opiate screen