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The page below is a sample from the LabCE course Drug Testing Methods in the Clinical Toxicology Laboratory. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Cocaine is rapidly metabolized to benzoylecognine and cleared from plasma. The half-life of cocaine varies from 45 minutes to 90 minutes. Because of its short half-life, cocaine is usually not confirmed by GC/MS or LC/MS/MS. Instead, benzoylecognine, having a longer half-life of approximately six to eight hours will be confirmed. Benzoylecognine and can be detected in the urine for one to three days.