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A 29-year-old female of Philippine descent is seen by her physician for fatigue. The patient states that a relative told her that their family has a long history of anemia.

She presents with sclera icterus and her spleen is palpable. Routine blood work was initially ordered and these results were obtained:

CBC Parameter

Patient Result

Reference Intervals

WBC6.1 X 10 9/L4.0 - 10.5 X 109/L
RBC4.84 X 1012/L3.50 - 5.50 X 1012/L


8.4 g/dL12.0 - 16.0 g/dL
Hematocrit28.8%36.0 - 48.0%
MCV59 fL80.0 - 100.0 fL
MCH17.4 pg26.0 - 34.0 pg
MCHC29.3 g/dL32.0 - 36.0 g/dL
RDW19.5 %11.0 - 15.0 %
Platelets591 X 109/L150 - 400 X 109/L

A peripheral blood smear is reviewed, revealing codocytes (target cells), as indicated by the blue arrows, and schizocytes (fragmented RBCs), as indicated by the red arrows. The majority of the RBCs that were seen in this smear were also microcytic and hypochromic.

What additional laboratory tests should be performed to aid in the diagnosis of this disorder and associated anemia?

More than one answer is correct. Please select all correct answers