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Normal Chromosome 16

Chromosome 16 contains the genetic codes for the zeta and alpha hemoglobin chains.

Each chromosome has two loci alpha chains α1 and α2. This equals a total of four gene loci coding for the alpha hemoglobin chain. See the image for a visual representation of these loci.

In the genotypic notation of alpha thalassemia an "α" represents the presence of an alpha locus. A "-" represents a deletion of a locus.

The notation for the normal number of alpha loci is αα/αα.

The amount of Hb A produced by this normal gene is 95-98 %.

(drawing modified from Harmening, 1999)