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The page below is a sample from the LabCE course HER2 Testing in Breast Cancer. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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HER2 FISH Specimen Handling Requirements

The HER2 2013 guidelines from CAP/ASCO apply to all IHC and FISH methodologies.
Excisional specimens should be fixed in 10% neutral buffered formalin (NBF) for 6 – 72 hours
  • If HER2 FISH results are negative, and the fixation time is known to be longer or shorter, this should be noted.
  • If alternative fixative is used, the fixative must be validated against results for the same specimens fixed in 10% NBF.
  • If an alternative fixative is used, the laboratory's director is responsible for test performance.