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The page below is a sample from the LabCE course HER2 Testing in Breast Cancer. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Discordant Results between Immunohistochemistry (IHC) and Fluorescence in Situ Hybridization (FISH)

Discordant results:
  • IHC is 3+ but FISH is negative for amplification
  • IHC < 2+ but FISH is positive for amplification
Each type of discordance is observed in approximately 3% of cases.