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The page below is a sample from the LabCE course Histology Special Stains: Connective Tissue. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Jones Methenamine Silver demonstrating Renal Basement Membrane

Jones' Methenamine Silver Stain (JMS) - Diagnostic Applications

The Jones' Methenamine Silver Stain (JMS) is used to demonstrate glomerular basement membrane in sections of kidney. Basement membranes are a type of connective tissue that epithelial cells rest upon. In the kidney, glomerular basement membranes serve as filters. Thickened glomerular basement membrane are often a sign of kidney disease and diabetes. These membranes are significantly difficult to distinguish with H&E staining.