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The page below is a sample from the LabCE course Variations in White Cell Morphology -- Granulocytes. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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May-Hegglin Anomaly

May-Hegglin anomaly is an autosomal dominant condition characterized by the presence of pale blue inclusions in neutrophils called May-Hegglin bodies (black arrow in image). May-Hegglin bodies, which are described as Döhle-like, are prominent and randomly distributed throughout the cytoplasm; inclusions can also occur in eosinophils, basophils, and monocytes. Additional findings include giant platelets (red arrow in image), and occasional thrombocytopenia.
Acquired forms of this anomaly may also occur as a result of the use of cytotoxic drugs.
The black arrow in the image points to a May-Hegglin body . The red arrow indicates a giant platelet, a characteristic that also helps to identify the anomaly.