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The page below is a sample from the LabCE course Variations in White Cell Morphology -- Granulocytes. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Single-Lobed Pelger-Huet Cells

This mature neutrophil has a single nuclear lobe. The nuclear chromatin is dense. Cells such as this and the previously shown bilobed "pince-nez" form may be seen with inherited Pelger-Huet or acquired pseudo Pelger-Huet.
*Note: When examining a slide made from an EDTA tube of normal blood, an occasional cell containing a round pyknotic nucleus and neutrophilic-appearing cytoplasm may be seen. Rare cells such as these do not indicate the presence of Pelger-Huet anomaly.