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The page below is a sample from the LabCE course Histology Special Stains: Nervous Tissue. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Histology Special Stains: Nervous Tissue (online CE course) »

Luxol Fast Blue (LFB) - Cresyl Violet Staining - Diagnostic Applications

When neuronal injuries occur, Nissl substance is lost. If axon degeneration is present, the myelin covering also breaks down. The loss of Nissl substance (chromatolysis) and the breakdown of the myelin (demyelination) are indicative of neural injuries and other diseases like Alzheimer's. By combining the LFB and cresyl violet staining procedures, BOTH Nissl substance and myelin can be demonstrated, or the lack thereof.