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The page below is a sample from the LabCE course Histology Special Stains: Nervous Tissue. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Histology of the Nervous System: Neurofibrillary Tangles (NFTs)

Neurofibrials are found in the cytoplasm of the cell body, axon and dendrites. They consist of a network of neurofilament and microtubules. Neurofibrillary tangles (NFTs) form inside the neuron when a microtubule associated protein, known as tau, aggragates into insoluble paired helical filaments. It is believed that when NFTs form inside the cell, it causes the neuron to become stressed and eventually die. The presence of NFTs in nervous tissues is recognized as a primary marker of Alzheimer's disease.