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The page below is a sample from the LabCE course Hereditary Hemochromatosis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Definitive Tests for Iron Overload

Measuring the amount of iron deposited in the liver is considered definitive for iron overload. This may be done by liver biopsy, computed tomography (CT), or magnetic resonance imaging (MRI). Demonstrating iron in parenchymal liver cells helps determine disease severity. Liver sections obtained by biopsy are stained with Perls Prussian blue which stains iron present in parenchymal cells. A photomicrograph of this reaction is shown.
Although liver biopsy may not be necessary for diagnosing HH, it offers the advantage of detecting liver fibrosis if present. Molecular tests for mutations associated with HH are considered the gold standard of current HH testing. Liver biopsy is not needed for diagnosing all patients suspected of having HH, but may be ordered in some cases.

Image is courtesy of John Woosley, MD.