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The page below is a sample from the LabCE course Liver Biopsies: Anatomy and Histological Considerations. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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An H&E stained liver biopsy demonstrating normal liver architecture.

H&E stained liver biopsy demonstrating hepatocellular carcinoma (HCC)

Tumors: Malignant

Malignant refers to cells that are cancerous. Cancerous cells have the ability to multiply and spread through the human body. Common features of malignant cells are outlined below and are illustrated in the images:
  • Mitotic (cellular division)
  • Cytoplasmic and Nuclear Hyperchromasia (increased staining)
  • Disorganization (cellular polarity)
  • Pleomorphic (variation in size and shape of cell and nucleus)
  • Increased nuclear-cytoplasmic ratio (N:C)
  • Pronounced nuclei
  • Desmoplasic (connective tissue cells respond and form collagenous material)