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The page below is a sample from the LabCE course Liver Biopsies: Anatomy and Histological Considerations. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Benign Inflammatory Metabolic Disease: Non-Alcoholic Steatohepatitis (NASH)

Non-alcoholic steatohepatitis (NASH) is a condition that demonstrates histologic characteristics similar to those of alcoholic liver disease in an individual who does not consume alcohol. Liver biopsy characteristics of NASH are fatty changes, hepatocellular necrosis, the presence of Mallory hyalin, and sometimes fibrosis. The quantity and patterns of these characteristics histologically allow pathologists to distinguish alcoholic liver disease from NASH in correlation with a history of alcohol consumption. NASH is most commonly observed in diabetic patients who are overweight.