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The page below is a sample from the LabCE course Liver Biopsies: Anatomy and Histological Considerations. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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A liver biopsy section demonstrating several forms of artifact such as chatter,
folds, and sponge artifact.


As in any specimen, liver biopsies are subject to microtomy artifacts.
Examples of artifacts are:
  • Folds or creases in the tissue section
  • Formalin pigment
  • Section compression
  • Waterbath contaminants
  • Knife lines
  • Chatter from rapid sectioning
  • Chatter from improper rehydration of tissue