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The page below is a sample from the LabCE course Liver Biopsies: Anatomy and Histological Considerations. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Connective Tissue: Type III Collagen

Type III collagen or reticular connective tissue provides the architectural framework for lymphatic tissue and organs such as the liver and spleen. Reticulin fibers form a honeycomb reticulin network where the cell types are deposited and/or anchored, providing structure in organs that can expand. Reticulin fibers cannot be visualized in a hematoxylin and eosin (H&E) stained slide. Reticulin fibers are argyrophilic, meaning that these tissue elements will appear black as a result of a chemical reaction in which a silver solution using the aid of a chemical reducer brings the silver into to a visible form.