Home Products Most Popular Contact
No items in your cart.
The page below is a sample from the LabCE course Cardiac Biomarkers. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Cardiac Biomarkers (online CE course) »
How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 123 CE courses, most popular
$95 Add to cart
Pick Your Courses
Up to 8 CE hours
$50 Add to cart
Individual course$20 Add to cart

Troponins

Serum troponin testing remains the most widely used and most definitive marker of myocyte injury.

What is troponin?
The troponin class of proteins are all contractile proteins that regulate muscle contractions; they work with calcium ions and another protein called tropomyosin. There are three types of troponin proteins:
  • Troponin C -- Calcium-binding component
  • Troponin I -- Inhibitory component
  • Troponin T -- Tropomyosin-binding component
Troponins are found in cardiac muscle and in slow-twitch and fast-twitch skeletal muscles.
  • Troponin C is found in both cardiac and skeletal muscle in the same form.
  • Troponin I has a specific form found in cardiac muscle, cTnI
  • Troponin T also has a cardiac-specific form, cTnT.
Unlike the CK enzymes, troponins, specifically cTnI and cTnT, are much more specific to myocardial tissue, making them superior markers for cardiac testing. If cTnI or cTnT are detected in the serum, we can be fairly certain myocardial damage is present. Consequently, CK-MB testing has largely been replaced with troponin testing. Many argue that CK-MB testing should, in fact, now be considered obsolete.