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The page below is a sample from the LabCE course Myelodysplastic Syndromes (MDS). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Normal megakaryocyte

Dysplastic Megakaryocytic Cell Line (Dysmegakaryopoiesis)

Normal megakaryocytes measure approximately 20-90 µm in diameter and have a multilobated nucleus (please refer to the image on the right).
Dysplastic megakaryocytes are:
  • Micro-megakaryocytes: smaller than 20 µm
  • Hypolobated megakaryocytes: megakaryocyte with two attached lobes
  • Monolobated megakaryocytes: megakaryocyte with single lobe
  • Megakaryocytes with separated nuclei: megakaryocyte with lobes completely separated
Examples of Dysplastic Megakaryocytic Cells:
Hypo-lobated megakaryocyte
Megakaryocyte with separated nuclei
Monolobated megakaryocyte