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The page below is a sample from the LabCE course Myelodysplastic Syndromes (MDS). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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The Classification of Myelodysplastic Syndromes (MDS), continued

MDS with single lineage dysplasia: (MDS-SLD)
  • This group manifests a single myeloid line dysplasia (erythroid, granulocytic, or megakaryocytic)
  • The cytopenia is manifested in one or two cell lines
  • Bone marrow blasts: < 5% (normal)
  • Peripheral blood blasts: < 1%
MDS with multilineage dysplasia: (MDS-MLD)
  • This group manifests significant dysplasia in two or three of the myeloid cell lines
  • The cytopenia is manifested in one to three myeloid cell lines
  • Bone marrow blasts: < 5% (normal)
  • Peripheral blood blasts: < 1%
MDS with ring sideroblasts: (MDS-RS)
  • This group manifests dysplasia in one cell line, or multiple cell lines.
  • The cytopenia is manifested in one to three myeloid cell lines
  • The Prussian blue (iron) stain of the aspirate smear show 15% or more ring sideroblasts
  • Bone marrow blasts: < 5% (normal)
  • Peripheral blood blasts: < 1%
MDS with excess blasts: (MDS-EB)
  • MDS-EB-1: Bone marrow blasts 5%-9% , peripheral blood blasts 2%-4% (abnormal)
  • MDS-EB-2: Bone marrow blasts 10%-19%, peripheral blood blasts 5%-19% (abnormal)
  • Cytopenia found in one to three cell lines
  • Dysplasia found in zero to three cell lines
MDS with isolated deletion of 5(q) chromosome:
  • This MDS is more prevalent in females, with a median age of 67 years-old
  • May demonstrate normal or high platelet counts, and a macrocytic, non-megaloblastic anemia
  • The bone marrow shows hypolobated, and monolobated megakaryocytes
  • Bone marrow blasts: < 5% (normal)
  • Peripheral blood blasts: < 1%