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The page below is a sample from the LabCE course Overview Of Major Antigens of the Rh Blood Group System. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Discussion of Rh Case Study

The patient is a multiply transfused female who has had several pregnancies, therefore her exposure to foreign red cells is fairly significant. During previous episodes of pre-transfusion testing her antibody screen has been negative (i.e. no alloantibodies demonstrated). The most recent results shown in the case study indicate that her antibody screen is now positive. One of the two screen cells reacts at a strength of 2+. Two units of red cells were ordered to be transfused, therefore an antibody identification panel must be performed in order to identify alloantibody(ies) present in the serum/plasma. Based on the interpretation of the antibody panel, units of red cells that are negative for the corresponding antigen(s) must be crossmatched through the antiglobulin phase prior to transfusion.