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The page below is a sample from the LabCE course Hallmarks and Signaling of Cancer Cells. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Cancer Hallmark #5: Generating New Blood Vessels

Cancer cells are capable of generating newly formed blood vessels, a phenomenon called angiogenesis or more precisely, neo-angiogenesis, to facilitate cancer cell metastasis, defined as motility and migration of cancerous cells to distant cells, tissues, and organs.
Transforming growth factor beta (TGFβ), one of the two cell cycle checkpoint proteins along with p53 as we have discussed earlier, play an essential role in mediating angiogenesis in cancer cells by promoting activities of angiogenic factors such as VEGF (vascular epidermal growth factor).
It is important to point out that angiogenesis is essential for tumor growth at primary tumor sites to ensure nutrient supply as well as secondary tumor sites as a result of metastasis.