Secondary Hemostasis: The Intrinsic Pathway, continued

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Secondary Hemostasis: The Intrinsic Pathway, continued

Here is where the "cascade" or "waterfall" nomenclature becomes evident as each activated factor triggers the conversion and activation of subsequent factors.
  1. Factor XIIa catalyzes the conversion of factor XI into XIa, while in the presence of HMWK. Note: This reaction can occur without HMWK, but will be much slower.