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The page below is a sample from the LabCE course Fundamentals of Hemostasis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Coagulation Factors in the Coagulation Cascade

As you can see in the image below, there is a cascade of biochemical reactions which takes place in order for fibrin strands to be created in secondary hemostasis. Each roman numeral below represents a specific coagulation factor of that number. These coagulation factors circulate in a non-activated form in our bloodstream at all times. When a vessel injury occurs, the factors become activated, one at a time, from the previous biochemical reaction before it.
The next slides will introduce the extrinsic, intrinsic, and common pathways, which compose the secondary hemostatic process.