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The page below is a sample from the LabCE course Drug Metabolism. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Factors Affecting Drug Metabolism

We have already discussed some important factors that affect drug metabolism, including genetic polymorphisms, enzyme inhibition, enzyme induction, and first pass metabolism. You should be aware by now that there is a great deal of variation in the metabolic reactions that produce drug metabolites. The extent to which a drug is metabolized by one individual can be dramatically different than that of another. Thus, the effect a drug will have on one individual can be dramatically different than the effect it has on another.