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The page below is a sample from the LabCE course Drug Metabolism. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Enzyme Inhibition, continued

CYP3A4 is involved in about 50% of drug metabolism, so there is a high risk of drug-to-drug interactions with this enzyme. Ritonavir (trade name Norvir - Abbott Laboratories) is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS and is a potent inhibitor of CYP3A4.
Substrates of CYP2D6 include tricyclic antidepressants, antipsychotics (eg, haloperidol), MDMA, SSRIs, beta blockers, and opiates. Drug-to-drug interactions can occur with all of these drugs when taken in combination with CYP2D6 inhibitors.