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Hemoglobinopathies: Hemoglobin S Disorders (Online CE Course)

(based on 206 customer ratings)

Author: Lillian Mundt, EdD, MLS(ASCP)SH
Reviewers: David J. Moffa, PhD, BCLD; Pinal Patel, MT (AMT)

Sickle cells are some of the most readily identifiable abnormal red blood cells that may be encountered on a manual differential and observation of them will assist in the positive identification of a hemoglobin S disorder. However, they are not present in all hemoglobin S disorders, or may not be present in all stages of a disorder.

This course will update you on the laboratory testing that is currently being used to diagnose and differentiate between the various forms of hemoglobin S disorders. You will also learn about the clinical symptoms that are associated with each one.

The course concludes with several case studies that will provide you with the opportunity to apply what you learned in the course.

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1.5 hour(s)
Course number 578-043-18, approved through 8/31/2020
Course number 20-631299, approved through 9/1/2020


  • Differentiate among structural abnormalities comprising the hemoglobinopathies.
  • Describe sickle cell disorders.
  • Explain the molecular basis for sickle cell hemoglobins.
  • Describe the process of sickle cell formation.
  • Identify contributors to the sickling process.
  • List the clinical manifestations of the various forms of sickle cell disorders.
  • Compare and contrast laboratory findings for sickle cell disorders.
  • Differentiate among the various forms of sickle cell disorders.
  • Describe therapies used in the treatment of sickle cell disorders.
  • Interpret laboratory results for sickle cell hemoglobin case studies.

Customer Ratings

(based on 206 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Hemoglobinopathies
      • Hemoglobinopathies
      • Examples of Structural Abnormalities
      • Hemoglobinopathies can be caused by all of the following structural defects EXCEPT:
  • Sickle Cell Disorders
  • The Sickling Process
      • Sickling Process Overview
      • The Sickling Process
      • The Sickling Process, continued
      • Normal Blood Flow
      • Blood Flow During Sickling
      • Vascular Occlusion
      • Cellular Dehydration
      • The first time a cell containing Hb SS is deoxygenated, it forms an irreversibly sickled cell.
  • Clinical Manifestations of Sickle Cell Disease
      • Clinical Manifestations of Sickle Cell Disease (SCD)
      • Vaso-occlusive Crisis
      • Vaso-occlusive Crisis, continued
      • Sequestration Crisis
      • Hemolytic Crisis
      • Aplastic Crisis
      • In sickle cell anemia, an increased amount of which of the following surface antigens on reticulocytes may allow platelets to form a bridge between th...
      • Which of the following will increase during hemolysis?
      • Complications
      • Risk Factors
      • Which of these could cause a sickling event?
  • Treatment of Sickle Cell Disease
  • Laboratory Findings in Sickle Cell Disorders
      • Laboratory Diagnosis
      • Comparison of Laboratory Results Among Hemoglobin S Disorders
    • Solubility Test
      • Solubility Test
      • Solubility Test Errors
    • Hemoglobin Electrophoresis
    • Red Blood Cell Morphologies in Sickle Cell Anemias
  • Case Studies
    • Sickle Cell Trait
      • CBC Results and RBC Morphology
      • Hemoglobin Electrophoresis
    • Sickle Cell Disease
    • Hemoglobin SC Disease
    • HbS / Beta thalassemia
      • CBC and RBC Morphology
      • Hemoglobin Electrophoresis
    • HbS with Hereditary Persistance of Fetal Hemoglobin (HPFH)
  • References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical laboratory professionals and other healthcare personnel who have an interest in this subject matter. This course is also appropriate for medical laboratory science and medical laboratory technician students and pathology residents.
Author Information: Lillian Mundt, EdD, MLS(ASCP)SH is currently employed by AMITA Adventist Hinsdale Hospital in the Molecular Pathology Department. She received her Bachelor of Arts degree in Medical Technology from Aurora College, Aurora, Illinois. Her graduate work was completed at Governor's State University, University Park, Illinois, from which she received her Master of Health Science in Allied Health Professions Education; her doctorate in Educational Leadership was earned from the University of Phoenix. Her work experience includes a position as a medical technologist in hematology for 30 plus years at Hinsdale Hospital, Department of Pathology. Lillian also taught at Hinsdale Hospital School of Medical Technology from 1981 until it closed in 1994 and Rosalind Franklin University of Medicine and Science Department of Clinical Laboratory Sciences from 1994 until the program closed in 2009.
Reviewer Information: David J. Moffa, PhD, BCLD, has over 30 years of experience in the healthcare industry as an executive manager, clinical laboratory director, and medical laboratory scientist. He is currently a technical consultant for Kentmere Healthcare, Wilmington, DE, and until his retirement, was the Regional Director for LabCorp, Inc. He holds a PhD in medical biochemistry from the School of Medicine, West Virginia University.
Reviewer Information: Pinal Patel, MT (AMT), is a Laboratory Education Specialist at Cleveland Clinic Foundation in Cleveland, Ohio. She has been with Cleveland Clinic since 2005 and worked as Medical Technologist in Pathology and Laboratory Medicine and transitioned to Educational Specialist role in 2016. She received Bachelor degree in Science major in Microbiology from Gujarat State University, India. She is a member of American Society of Clinical Laboratory Science (ASCLS). 

Electro patterns sickle cell
edit 2_sickle cells
HbS acid ep
peripheral picture_SS
target cells_arrows
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Electro patterns sickle cell

edit 2_sickle cells

HbS acid ep


peripheral picture_SS


target cells_arrows