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Transfusion Reactions (Online CE Course)

(based on 1,047 customer ratings)

Author: Erin Tretter, MT(ASCP)
Reviewer: Barbara Cebulski, MS, MLS(ASCP)

What are the risks associated with blood transfusion? As a laboratory professional involved in blood preparation for transfusion, do you know what steps you can take to minimize those risks? If a patient starts to exhibit various symptoms during or after a transfusion, would you know how to interpret those symptoms and what actions to take to prevent harm to the patient? These are all important questions that are asked and answered by our new course, Transfusion Reactions. This course covers important types of transfusion reactions, including acute hemolytic transfusion reactions, transfusion-related acute lung injury, and transfusion-associated graft versus host disease. If you are a part of the health care team that is involved in the processing and administration of blood products, this course will reinforce those policies and procedures that you may already know, but are important to review. This course will update your knowledge about the various types of reactions that occur and their associated symptoms. Even though you may not be involved in the clinical part of the transfusion process, it is important to understand the big picture to recognize how important your job is to ensure patient transfusion safety.

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Continuing Education Credits

Florida Board of Clinical Laboratory Personnel Credit Hours - General (Blood Banking / Immunohematology): 1.5 hour(s)
Course number 20-547963, approved through 9/1/2020

Objectives

  • Define transfusion reaction.
  • Identify the risks of transfusions.
  • Compare and contrast immediate hemolytic transfusion reactions and delayed hemolytic transfusion reactions.
  • List and define the types of nonhemolytic transfusion reactions.
  • List the laboratory findings associated with hemolytic and nonhemolytic transfusion reactions.
  • Discuss the definition, pathophysiology, signs, symptoms, therapies, prevention, and clinical work-up of hemolytic and nonhemolytic transfusion reactions.
  • List the antibodies associated with hemolytic transfusion reactions.
  • List the steps and procedures to follow in a laboratory investigation of a transfusion reaction.

Customer Ratings

(based on 1,047 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Adverse Effects of Blood Transfusions
  • Blood Component Transfusion Risks
  • Acute Immunologic Transfusion Reactions
    • Acute Hemolytic Transfusion Reactions
      • Causes of Acute Hemolytic Transfusion Reaction (AHTR)
      • Clinical Signs and Symptoms
      • Initial Transfusion Reaction Investigation
      • Additional Testing
      • Management and Prevention
      • An acute hemolytic reaction may be caused by which of the following? (Choose all that apply)
    • Febrile Transfusion Reactions
      • Febrile Nonhemolytic Transfusion Reactions: Definition, Manifestation, and Prevalence
      • Diagnosis, Treatment, and Prevention of FNHTR
    • Allergic Transfusion Reaction
    • Transfusion-Related Acute Lung Injury (TRALI)
      • Definition and Epidemiology
      • Clinical Presentation and Laboratory Findings
      • Pathophysiology
      • Diagnosis, Treatment, and Prognosis
      • Prevention of Transfusion-Related Acute Lung Injury (TRALI)
      • Which type of antibodies are known to cause transfusion-related acute lung injury (TRALI) reactions?
  • Acute Nonimmunologic Transfusion Reactions
  • Summary of Additional Testing in Acute (Immediate) Transfusion Reaction Investigations
      • Table: Additional Testing That May Be Ordered for Acute (Immediate) Transfusion Reaction Investigations
  • Delayed Immunologic Transfusion Reactions
    • Delayed Hemolytic Transfusion Reactions
      • Delayed Hemolytic Transfusion Reaction (DHTR)
      • DHTR: Diagnosis
      • Severe DHTR and Sickle Cell Anemia
      • Delayed hemolytic transfusion reactions (DHTR) typically occur 3 hours after transfusion.
    • Transfusion-Associated Graft-Versus-Host Disease (TA-GVHD)
    • Post-Transfusion Purpura (PTP)
      • Definition/Manifestation/Prevalence
      • Pathophysiology, Treatment, and Prevention of Post-Transfusion Purpura (PTP)
      • Which of the following patients are at risk for transfusion-associated graft versus host disease (TA-GVHD) and require irradiated cellular blood produ...
      • Post-transfusion purpura (PTP) is characterized by which of the following?
  • Delayed NonImmunologic Transfusion Reactions
      • Iron Overload
      • Disease Transmission
  • Investigation of a Delayed Transfusion Reaction
      • Investigation of a Delayed Transfusion Reaction
  • Reporting Transfusion Reactions
      • Recording and Reporting Transfusion Reactions
  • References
      • References

Additional Information

Level of instruction: Intermediate
 
Intended audience: Medical laboratory scientists, medical technologists, and technicians, This course is also appropriate for clinical laboratory science students and pathology residents.
Author information: Erin Tretter, MT(ASCP), is currently the Point of Care Coordinator and Lead Medical Technologist at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She received her BS in Medical Technology from California University of Pennsylvania and has experience as a Generalist, including Blood Bank, Hematology and Chemistry. Erin is the Blood Bank Clinical Instructor for the Clinical Laboratory Science Program at St. Christopher’s and has four years experience teaching immunohematology concepts and laboratory procedures to Medical Technology students. She has also provided blood bank training for laboratory technologists and medical students. Erin is currently obtaining a Master’s in Business Administration from Florida Institute of Technology where she is a member of the Phi Kappa Phi Honor’s Society.
 
Reviewer information: Barbara Cebulski, MS, MLS(ASCP) has over 40 years of experience in the medical laboratory profession as a technologist, section supervisor, and laboratory manager. She was an Inspection and Technical Specialist for nine years with the College of American Pathologists in the Laboratory Accreditation Program and, until her retirement in 2015, was Program Director for MediaLab, Inc. Barbara holds a Masters in Instructional Technology from Georgia State University.
 
Course information: This course is a review of clinical and laboratory recognition of transfusion reactions and the responsibilities of both areas for prevention of and proper response to a suspected reaction. 

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Keywords

These are the most common topics and keywords covered in Transfusion Reactions:

ahtr intravascular pathophysiology blood bank platelets serologic fnhtr bone marrow ucm205620 infectious bacterial dhtr diuretics anamnestic non-hemolytic rbcs identification reticuloendothelial evaluation citrate allergen infiltrates urinalysis records biologicsbloodvaccines extravascular jaundice immunocompromised medicine nonhemolytic heart roback potassium methods liver deficiency hypoxemia mast cells diseases pathogens allows dhtrs bacteria immunodeficiency histamines philadelphia symptoms churchill contaminated red blood cells edema hemoglobin transfusions disease red blood cell fetuses glucose scrub antibodies environment premedication antibody diagnosis urine sickle organs autologous b-type lymphocytes antigen anemias alloantibodies endotoxins laboratory blood bilateral indefinitely transfusion alloantibody differential errors pre-storage anti-hla donors matched coagulation body tubing hemoglobinuria treatment eligibility fatalities transfusionist antiglobulin pregnancy acute transfused oxygen oliguria procedures urticarial silberstein immune-mediated hematocrit misidentification adverse cellular annual saline transfusiondonationfatalities post-transfusion transfusion-associated hemolysis anemia safetyavailability anti-iga allergic transfusion-related leukocyte peptide crossmatch chemical febrile reportaproblem exposure labeling physician natriuretic arrhythmias organisms bilirubin samples pre-transfusion trali donate antigen-antibody respiratory anderson hypersensitivity granulocyte platelet cytokines fnhtrs immune drug multiparous providers toxicity ta-gvhd hives antigens concentration thrombocytopenia airway hypotension cryoprecipitate lysis intracellular hillyer downloads livingstone dyspnea rigors anaphylactoid diarrhea hemolytic lung alloimmunization contamination infection clinical symptom cardiac label ness serum soluble taco urinary donor radiograph stem intravenous blood banking disinfection abdominal appears neonates medication plasma cells anaphylactic
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