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Transfusion Reactions (Online CE Course)

(based on 1,068 customer ratings)

Author: Erin Tretter, MT(ASCP)
Reviewer: Barbara Cebulski, MS, MLS(ASCP)

What are the risks associated with blood transfusion? As a laboratory professional involved in blood preparation for transfusion, do you know what steps you can take to minimize those risks? If a patient starts to exhibit various symptoms during or after a transfusion, would you know how to interpret those symptoms and what actions to take to prevent harm to the patient? These are all important questions that are asked and answered by our new course, Transfusion Reactions. This course covers important types of transfusion reactions, including acute hemolytic transfusion reactions, transfusion-related acute lung injury, and transfusion-associated graft versus host disease. If you are a part of the health care team that is involved in the processing and administration of blood products, this course will reinforce those policies and procedures that you may already know, but are important to review. This course will update your knowledge about the various types of reactions that occur and their associated symptoms. Even though you may not be involved in the clinical part of the transfusion process, it is important to understand the big picture to recognize how important your job is to ensure patient transfusion safety.

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Continuing Education Credits

Florida Board of Clinical Laboratory Personnel Credit Hours - General (Blood Banking / Immunohematology): 1.5 hour(s)
Course number 20-547963, approved through 9/1/2020

Objectives

  • Define transfusion reaction.
  • Identify the risks of transfusions.
  • Compare and contrast immediate hemolytic transfusion reactions and delayed hemolytic transfusion reactions.
  • List and define the types of nonhemolytic transfusion reactions.
  • List the laboratory findings associated with hemolytic and nonhemolytic transfusion reactions.
  • Discuss the definition, pathophysiology, signs, symptoms, therapies, prevention, and clinical work-up of hemolytic and nonhemolytic transfusion reactions.
  • List the antibodies associated with hemolytic transfusion reactions.
  • List the steps and procedures to follow in a laboratory investigation of a transfusion reaction.

Customer Ratings

(based on 1,068 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Adverse Effects of Blood Transfusions
      • Transfusion Reactions: Introduction
  • Blood Component Transfusion Risks
  • Acute Immunologic Transfusion Reactions
      • In Vivo Red Cell Destruction
    • Acute Hemolytic Transfusion Reactions
      • Causes of Acute Hemolytic Transfusion Reaction (AHTR)
      • Clinical Signs and Symptoms
      • Initial Transfusion Reaction Investigation
      • Additional Testing
      • Management and Prevention
      • An acute hemolytic reaction may be caused by which of the following? (Choose all that apply)
    • Febrile Transfusion Reactions
    • Allergic Transfusion Reaction
      • Definition, Manifestations, and Prevalence of Allergic Reactions Related to Transfusion
      • Pathophysiology
      • Diagnosis, Treatment, and Prevention
      • A febrile nonhemolytic transfusion reaction (FNHTR) is characterized by which of the following symptoms?
      • Premedication with antihistamines may prevent an allergic reaction in patients with a history of multiple urticarial transfusion reactions.
    • Transfusion-Related Acute Lung Injury (TRALI)
  • Acute Nonimmunologic Transfusion Reactions
    • Bacterial Contamination
      • Presentation and Prevalence of Bacterial Contamination
      • Bacteria Implicated in Contamination
      • Sources of Contamination
      • Reducing Transfusion-Associated Septic Reactions
      • Which type of blood component is MOST often implicated in bacterial contamination?
    • Circulatory Overload
      • Transfusion-Associated Circulatory Overload (TACO)
    • Physical/Chemical Hemolysis
      • Acute Pain and Hypotensive Reactions
  • Summary of Additional Testing in Acute (Immediate) Transfusion Reaction Investigations
  • Delayed Immunologic Transfusion Reactions
    • Delayed Hemolytic Transfusion Reactions
    • Transfusion-Associated Graft-Versus-Host Disease (TA-GVHD)
    • Post-Transfusion Purpura (PTP)
  • Delayed NonImmunologic Transfusion Reactions
  • Investigation of a Delayed Transfusion Reaction
      • Investigation of a Delayed Transfusion Reaction
  • Reporting Transfusion Reactions
  • References

Additional Information

Level of instruction: Intermediate
 
Intended audience: Medical laboratory scientists, medical technologists, and technicians, This course is also appropriate for clinical laboratory science students and pathology residents.
Author information: Erin Tretter, MT(ASCP), is currently the Point of Care Coordinator and Lead Medical Technologist at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She received her BS in Medical Technology from California University of Pennsylvania and has experience as a Generalist, including Blood Bank, Hematology and Chemistry. Erin is the Blood Bank Clinical Instructor for the Clinical Laboratory Science Program at St. Christopher’s and has four years experience teaching immunohematology concepts and laboratory procedures to Medical Technology students. She has also provided blood bank training for laboratory technologists and medical students. Erin is currently obtaining a Master’s in Business Administration from Florida Institute of Technology where she is a member of the Phi Kappa Phi Honor’s Society.
 
Reviewer information: Barbara Cebulski, MS, MLS(ASCP) has over 40 years of experience in the medical laboratory profession as a technologist, section supervisor, and laboratory manager. She was an Inspection and Technical Specialist for nine years with the College of American Pathologists in the Laboratory Accreditation Program and, until her retirement in 2015, was Program Director for MediaLab, Inc. Barbara holds a Masters in Instructional Technology from Georgia State University.
 
Course information: This course is a review of clinical and laboratory recognition of transfusion reactions and the responsibilities of both areas for prevention of and proper response to a suspected reaction. 

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Keywords

These are the most common topics and keywords covered in Transfusion Reactions:

organs deficiency multiparous diarrhea allows dhtrs bacterial immune abdominal edema ucm205620 hematocrit scrub methods transfused organisms lung blood bank alloantibodies silberstein bone marrow anderson antigen-antibody mast cells laboratory acute pre-storage appears extravascular transfusion-related labeling toxicity anemia jaundice ahtr physician anaphylactic eligibility bilirubin samples bacteria urticarial allergen endotoxins bilateral taco hemolytic pathophysiology crossmatch anti-hla hemoglobin trali medication diuretics oxygen platelets intracellular intravenous granulocyte clinical red blood cell febrile cardiac matched churchill immune-mediated reticuloendothelial infection urinalysis hypotension platelet transfusionist radiograph symptom thrombocytopenia tubing b-type contaminated cellular downloads serologic medicine hemoglobinuria cells annual anaphylactoid serum ness fetuses environment procedures anti-iga donate immunodeficiency post-transfusion dyspnea pre-transfusion alloimmunization safetyavailability histamines errors philadelphia indefinitely plasma pregnancy infiltrates nonhemolytic heart oliguria lysis potassium fnhtrs identification antigen airway stem differential donor hives blood banking natriuretic dhtr red blood cells premedication rbcs rigors exposure roback citrate immunocompromised ta-gvhd sickle disease hypersensitivity soluble transfusion-associated antigens pathogens coagulation urinary records autologous reportaproblem evaluation urine respiratory diseases biologicsbloodvaccines glucose antibody cryoprecipitate peptide treatment body drug misidentification fnhtr infectious donors saline chemical antibodies contamination transfusiondonationfatalities concentration cytokines hillyer diagnosis intravascular symptoms lymphocytes arrhythmias livingstone anamnestic fatalities blood providers neonates liver adverse transfusion leukocyte hemolysis antiglobulin anemias label allergic disinfection hypoxemia transfusions non-hemolytic alloantibody
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